Pneumococcal Pneumonia and the Risk of Stroke: A Population-Based Follow-Up Study

Li-Fu Chen, Hsin-Pai Chen, Yung-Sung Huang, Kuang-Yung Huang, Pesus Chou and Ching-Chih Lee

PLOS ONE, 2012, vol. 7, issue 12, 1-7

Abstract: Background: To investigate the risk of developing stroke in patients hospitalized following a diagnosis of pneumococcal pneumonia. Methods: The study cohorts comprised of patients hospitalized with a principal diagnosis of pneumococcal pneumonia (n = 745), with a random sampling of control individuals in 2004 (n = 1490). The Cox proportional hazard model was used to compare the stroke-free survival rate between the cohorts after adjusting for possible confounding and risk factors for a two-year follow up. Instrumental variable analysis (IVA) was used to address potential biases associated with measured and unmeasured confounding variables. Results: Of the 153 patients with stroke, 80 (10.7%) were from the pneumococcal pneumonia cohort, and 73 (4.9%) were from the control group. The risk of stroke was 3.65 times higher (95% confidence interval, 2.25–5.90; P

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0051452

DOI: 10.1371/journal.pone.0051452

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