MiR-27 as a Prognostic Marker for Breast Cancer Progression and Patient Survival

Wei Tang, Jiujun Zhu, Shicheng Su, Wei Wu, Qiang Liu, Fengxi Su and Fengyan Yu

PLOS ONE, 2012, vol. 7, issue 12, 1-7

Abstract: Background: MicroRNA-27a (miR-27a) is thought to be an onco-microRNA that promotes tumor growth and metastasis by downregulating ZBTB10. The potential predictive value of miR-27a was studied in breast cancer patients. Methods: The expression of miR-27a and ZBTB10 was examined in 102 breast cancer cases using in situ hybridization (ISH) and immunohistochemistry techniques and were evaluated semi-quantitatively by examining the staining index. The Correlation of miR-27a and ZBTB10 expression was analyed by Spearman Rank Correlation. The association of miR-27a and ZBTB10 expression with clinicopathological characteristics was analyzed using the χ2 test, and their effects on patient survival were analyzed by a log-rank test and the Kaplan-Meier method. Univariate and multivariate Cox regression analyses were used to evaluate the prognostic values of miR-27a and ZBTB10. Results: miR-27a was markedly up-regulated in invasive breast cancers that expressed low levels of ZBTB10 (P

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0051702

DOI: 10.1371/journal.pone.0051702

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