A Possible Genetic Link between MTHFR Genotype and Smoking Behavior

Michael Linnebank, Susanna Moskau, Alexander Semmler, Barbara Hoefgen, Gisela Bopp, Ulf Kallweit, Wolfgang Maier, Christian G Schütz and Ullrich Wüllner

PLOS ONE, 2012, vol. 7, issue 12, 1-4

Abstract: Background: Hyperhomocysteinemia is an independent risk factor for stroke and other vascular events. The variant methylenetetrahydrofolate reductase (MTHFR) C677T is associated with elevated homocysteine levels, cardiovascular disease and stroke, which supports a causal relationship between hyperhomocysteinemia and vascular disease. However, MTHFR variants have also been reported to be associated with smoking behavior, which could be an important confounder. Methodology/Principal Findings: We analyzed the MTHFR variants C677T and A1298C in two independent samples of 525 and 535 individuals, respectively. 21% of the non-smokers, but only 12% of the smokers were homozygous carriers of both MTHFR wildtype alleles, i.e. 677CC and 1298AA (Chi2 = 15.8; p

Date: 2012
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0053322

DOI: 10.1371/journal.pone.0053322

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