Interleukin-10 Promoter Gene Polymorphisms and Susceptibility to Asthma: A Meta-Analysis

Myung-Han Hyun, Chung-Ho Lee, Min-Hyung Kang, Bong-Kyung Park and Young Ho Lee

PLOS ONE, 2013, vol. 8, issue 1, 1-8

Abstract: Objective: The aim of this study was to explore whether the interleukin (IL)-10 polymorphisms and their haplotypes contribute to asthma susceptibility. Methods: MEDLINE, EMBASE and the COCHRANE library databases were utilized to identify available articles. A meta-analysis was conducted on IL-10 -1082 G/A, -819 C/T, -592 C/A polymorphisms, and their haplotypes and asthma. Results: Eleven studies involving 2,215 asthma patients and 2,170 controls were considered in the meta-analysis. The meta-analysis revealed no association between asthma and the IL-10 -1082 G allele [Odds ratio (OR) = 0.87, 95% Confidence interval (CI) = 0.68–1.12, p = 0.28]. However, meta-analysis of the five studies in Hardy-Weinburg equilibrium produced the relationship between the IL-10 -1082 G allele and asthma (OR = 0.71, 95% CI = 0.60–0.83, p

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0053758

DOI: 10.1371/journal.pone.0053758

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