Angiopoietin-2 Is Associated with Albuminuria and Microinflammation in Chronic Kidney Disease

Fan-Chi Chang, Tai-Shuan Lai, Chih-Kang Chiang, Yung-Ming Chen, Ming-Shiou Wu, Tzong-Shinn Chu, Kwan-Dun Wu and Shuei-Liong Lin

PLOS ONE, 2013, vol. 8, issue 3, 1-6

Abstract: Although cardiovascular disease (CVD) is the leading cause of mortality in patients with chronic kidney disease (CKD), the pathophysiology is not thoroughly understood. Given that elevated albuminuria or circulating angiopoietin-2 associates with CVD and mortality in CKD patients, we were intrigued by the relationship between albuminuria and angiopoietin-2. A total of 416 patients with CKD stages 3 to 5 were stratified by urine albumin-creatinine ratio as normoalbuminuria ( 300 mg/g). The levels of plasma angiopoietin-2 and vascular endothelial growth factor (VEGF) increased, and soluble Tie-2 decreased in the subgroups of albuminuria; whereas angiopoietin-1 did not change. Linear regression showed a positive correlation between urine albumin-creatinine ratio (ACR) and plasma angiopoietin-2 (correlation coefficient r = 0.301, 95% confidence interval 0.211–0.386, P

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0054668

DOI: 10.1371/journal.pone.0054668

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