Determinants of Oxygen and Carbon Dioxide Transfer during Extracorporeal Membrane Oxygenation in an Experimental Model of Multiple Organ Dysfunction Syndrome

Marcelo Park, Eduardo Leite Vieira Costa, Alexandre Toledo Maciel, Débora Prudêncio e Silva, Natalia Friedrich, Edzangela Vasconcelos Santos Barbosa, Adriana Sayuri Hirota, Guilherme Schettino and Luciano Cesar Pontes Azevedo

PLOS ONE, 2013, vol. 8, issue 1, 1-11

Abstract: Extracorporeal membrane oxygenation (ECMO) has gained renewed interest in the treatment of respiratory failure since the advent of the modern polymethylpentene membranes. Limited information exists, however, on the performance of these membranes in terms of gas transfers during multiple organ failure (MOF). We investigated determinants of oxygen and carbon dioxide transfer as well as biochemical alterations after the circulation of blood through the circuit in a pig model under ECMO support before and after induction of MOF. A predefined sequence of blood and sweep flows was tested before and after the induction of MOF with fecal peritonitis and saline lavage lung injury. In the multivariate analysis, oxygen transfer had a positive association with blood flow (slope = 66, P

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0054954

DOI: 10.1371/journal.pone.0054954

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