Replication and Predictive Value of SNPs Associated with Melanoma and Pigmentation Traits in a Southern European Case-Control Study

Irene Stefanaki, Orestis A Panagiotou, Elisavet Kodela, Helen Gogas, Katerina P Kypreou, Foteini Chatzinasiou, Vasiliki Nikolaou, Michaela Plaka, Iro Kalfa, Christina Antoniou, John P A Ioannidis, Evangelos Evangelou and Alexander J Stratigos

PLOS ONE, 2013, vol. 8, issue 2, 1-10

Abstract: Background: Genetic association studies have revealed numerous polymorphisms conferring susceptibility to melanoma. We aimed to replicate previously discovered melanoma-associated single-nucleotide polymorphisms (SNPs) in a Greek case-control population, and examine their predictive value. Methods: Based on a field synopsis of genetic variants of melanoma (MelGene), we genotyped 284 patients and 284 controls at 34 melanoma-associated SNPs of which 19 derived from GWAS. We tested each one of the 33 SNPs passing quality control for association with melanoma both with and without accounting for the presence of well-established phenotypic risk factors. We compared the risk allele frequencies between the Greek population and the HapMap CEU sample. Finally, we evaluated the predictive ability of the replicated SNPs. Results: Risk allele frequencies were significantly lower compared to the HapMap CEU for eight SNPs (rs16891982 – SLC45A2, rs12203592 – IRF4, rs258322 – CDK10, rs1805007 – MC1R, rs1805008 - MC1R, rs910873 - PIGU, rs17305573- PIGU, and rs1885120 - MTAP) and higher for one SNP (rs6001027 – PLA2G6) indicating a different profile of genetic susceptibility in the studied population. Previously identified effect estimates modestly correlated with those found in our population (r = 0.72, P

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0055712

DOI: 10.1371/journal.pone.0055712

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