Long-Term Prognostic Performance of Ki67 Rate in Early Stage, pT1-pT2, pN0, Invasive Breast Carcinoma

Fabien Reyal, David Hajage, Alexia Savignoni, Jean-Guillaume Feron, Marc Andrew Bollet, Youlia Kirova, Alain Fourquet, Jean-Yves Pierga, Paul Cottu, Veronique Dieras, Virginie Fourchotte, Fatima Laki, Severine Alran, Bernard Asselain, Anne Vincent-Salomon, Brigitte Sigal-Zafrani and Xavier Sastre-Garau

PLOS ONE, 2013, vol. 8, issue 3, 1-10

Abstract: Background: Molecular signatures may become of use in clinical practice to assess the prognosis of breast cancers. However, although international consensus conferences sustain the use of these new markers in the near future, concerns remain about their degree of discordance and cost-effectiveness in different international settings. The present study aims to validate Ki67 as prognostic factor in a large cohort of early-stage (pT1–pT2, pN0) breast cancer patients. Methods: 456 patients treated in 1995–1996 were identified in the Institut Curie database. Ki67 (MIB1) was retrospectively assessed by immunohistochemistry for all cases. The prognostic value of this index was compared to that of histological grade (HG), Estrogen receptor (ER) and HER2 status. Distant disease free interval, loco-regional recurrence, time-lapse from first metastatic diagnosis to death were analyzed. Results: All 456 patients were treated by lumpectomy plus axillary dissection and radiotherapy. 27 patients (5.9%) received systemic treatment. Tumors were classified as HG1 in 35%, HG2 in 42% and HG3 in 23% of cases. ER was expressed in 86% of the tumors, HER2 in 5% and 14% were triple negative. The median follow-up was 151 [5–191] months. Distant and loco-regional disease recurrences were observed in 16% and 18%, respectively. High (>20%) Ki67 rate [HR = 3 (1.8–4.8), p

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0055901

DOI: 10.1371/journal.pone.0055901

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