Evaluation of Copper Concentration in Subclinical Cases of White Muscle Disease and Its Relationship with Cardiac Troponin I

Forough Ataollahi, Mehrdad Mohri, Hesam A Seifi, Belinda Pingguan-Murphy, Wan Abu Bakar Wan Abas and Noor Azuan Abu Osman

PLOS ONE, 2013, vol. 8, issue 2, 1-5

Abstract: The present study aims to evaluate the serum level of copper (Cu) in lambs suffering from subclinical forms of white muscle disease (WMD) and its relationship with cardiac troponin I (cTn-I) as a novel biomarker of cardiovascular disorders. Ten milliliters of jugular blood were taken from 200 lambs less than one year old to measure serum concentrations of Cu, selenium (Se), and cTn-I. The subjects were divided into 2 groups, namely, the deficient group which included 36 lambs, and the control group which included 164 lambs according to the reference serum Se concentration (50 ng/mL). Serum Se levels in the deficient group were lower than 50 ng/mL. By contrast, the control group showed Se levels higher than 50 ng/mL. Differences among the serum Cu and cTn-I levels were determined in both groups. The mean ±SD and median of serum Cu and cTn-I levels in the deficient group were lower and higher than those in the control group, respectively. A significant positive correlation was observed between serum Cu and Se levels, and also serum Cu and Se levels showed a negative correlation with serum cTn-I concentrations. Stepwise linear regression analysis showed that serum Cu levels were correlated positively with serum Se levels (p

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0056163

DOI: 10.1371/journal.pone.0056163

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