CD133 Expression and the Prognosis of Colorectal Cancer: A Systematic Review and Meta-Analysis

Shicai Chen, Xinming Song, Zhihui Chen, Xinxin Li, Mingzhe Li, Haiying Liu and Jianchang Li

PLOS ONE, 2013, vol. 8, issue 2, 1-9

Abstract: Objective: CD133 has recently been reported as a marker of cancer stem-like cells in colorectal cancer (CRC). However, its predictive value in CRC still remains controversial. In this study, we aimed to evaluate the association between the expression of CD133 and clinicopathological features and the outcome of CRC patients by performing a meta-analysis. Methods: A comprehensive literature search for relevant studies published up to December 2012 was performed using PubMed, MEDLINE and ISI Web of Science. Only articles in which CD133 antigen was detected in situ localisation by immunohistochemical staining were included. This meta-analysis was done using RevMan 4.2 software. Results: We found that a total of 15 studies involving 810 CD133-high and 1487 CD133-low patients met the inclusion criteria for the analysis of 5-year overall survival (OS) rate. In a random-effects model, the results showed that CD133-high expression in colorectal cancer was an independent prognostic marker correlating with both OS rate (RR = 0.67, 95%CI 0.54–0.82, P

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0056380

DOI: 10.1371/journal.pone.0056380

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