Statins and the Risk of Lung Cancer: A Meta-Analysis

Min Tan, Xiaolian Song, Guoliang Zhang, Aimei Peng, Xuan Li, Ming Li, Yang Liu and Changhui Wang

PLOS ONE, 2013, vol. 8, issue 2, 1-9

Abstract: Purpose: Several epidemiologic studies have evaluated the association between statins and lung cancer risk, whereas randomized controlled trials (RCTs) on cardiovascular outcomes provide relevant data as a secondary end point. We conducted a meta-analysis of all relevant studies to examine this association. Methods: A systematic literature search up to March 2012 was performed in PubMed database. Study-specific risk estimates were pooled using a random-effects model. Results: Nineteen studies (5 RCTs and 14 observational studies) involving 38,013 lung cancer cases contributed to the analysis. They were grouped on the basis of study design, and separate meta-analyses were conducted. There was no evidence of an association between statin use and risk of lung cancer either among RCTs (relative risk [RR] 0.91, 95% confidence interval [CI] 0.76–1.09), among cohort studies (RR 0.94, 95% CI 0.82–1.07), or among case-control studies (RR 0.82, 95% CI 0.57–1.16). Low evidence of publication bias was found. However, statistically significant heterogeneity was found among cohort studies and among case-control studies. After excluding the studies contributing most to the heterogeneity, summary estimates were essentially unchanged. Conclusion: The results of our meta-analysis suggest that there is no association between statin use and the risk of lung cancer.

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0057349

DOI: 10.1371/journal.pone.0057349

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