The Effects of Computed Tomography with Iterative Reconstruction on Solid Pulmonary Nodule Volume Quantification

Martin J Willemink, Jaap Borstlap, Richard A P Takx, Arnold M R Schilham, Tim Leiner, Ricardo P J Budde and Pim A de Jong

PLOS ONE, 2013, vol. 8, issue 2, 1-6

Abstract: Background: The objectives of this study were to evaluate the influence of iterative reconstruction (IR) on pulmonary nodule volumetry with chest computed tomography (CT). Methods: Twenty patients (12 women and 8 men, mean age 61.9, range 32–87) underwent evaluation of pulmonary nodules with a 64-slice CT-scanner. Data were reconstructed using filtered back projection (FBP) and IR (Philips Healthcare, iDose4-levels 2, 4 and 6) at similar radiation dose. Volumetric nodule measurements were performed with semi-automatic software on thin slice reconstructions. Only solid pulmonary nodules were measured, no additional selection criteria were used for the nature of nodules. For intra-observer and inter-observer variability, measurements were performed once by one observer and twice by another observer. Algorithms were compared using the concordance correlation-coefficient (pc) and Friedman-test, and post-hoc analysis with the Wilcoxon-signed ranks-test with Bonferroni-correction (significance-level p

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0058053

DOI: 10.1371/journal.pone.0058053

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