Bronchodilator Responsiveness and Reported Respiratory Symptoms in an Adult Population

Wan C Tan, Jean Bourbeau, Paul Hernandez, Kenneth R Chapman, Robert Cowie, J Mark FitzGerald, Shawn Aaron, Darcy D Marciniuk, Francois Maltais, A Sonia Buist, Denis E O’Donnell and Don D Sin

PLOS ONE, 2013, vol. 8, issue 3, 1-8

Abstract: Background: The relationship between patient-reported symptoms and objective measures of lung function is poorly understood. Aim: To determine the association between responsiveness to bronchodilator and respiratory symptoms in random population samples. Methods: 4669 people aged 40 years and older from 8 sites in Canada completed interviewer-administered respiratory questionnaires and performed spirometry before and after administration of 200 ug of inhaled salbutamol. The effect of anthropometric variables, smoking exposure and doctor-diagnosed asthma (DDA) on bronchodilator responsiveness in forced expiratory volume in 1 second (FEV1) and in forced vital capacity (FVC) were evaluated. Multiple logistic regression was used to test for association between quintiles of increasing changes in FEV1 and in FVC after bronchodilator and several respiratory symptoms. Results: Determinants of bronchodilator change in FEV1 and FVC included age, DDA, smoking, respiratory drug use and female gender [p

Date: 2013
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0058932 (text/html)
https://journals.plos.org/plosone/article/file?id= ... 58932&type=printable (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0058932

DOI: 10.1371/journal.pone.0058932

Access Statistics for this article

More articles in PLOS ONE from Public Library of Science
Bibliographic data for series maintained by plosone ().