A Large Scale Gene-Centric Association Study of Lung Function in Newly-Hired Female Cotton Textile Workers with Endotoxin Exposure

Ruyang Zhang, Yang Zhao, Minjie Chu, Amar Mehta, Yongyue Wei, Yao Liu, Pengcheng Xun, Jianling Bai, Hao Yu, Li Su, Hongxi Zhang, Zhibin Hu, Hongbing Shen, Feng Chen and David C Christiani

PLOS ONE, 2013, vol. 8, issue 3, 1-10

Abstract: Background: Occupational exposure to endotoxin is associated with decrements in pulmonary function, but how much variation in this association is explained by genetic variants is not well understood. Objective: We aimed to identify single nucleotide polymorphisms (SNPs) that are associated with the rate of forced expiratory volume in one second (FEV1) decline by a large scale genetic association study in newly-hired healthy young female cotton textile workers. Methods: DNA samples were genotyped using the Illumina Human CVD BeadChip. Change rate in FEV1 was modeled as a function of each SNP genotype in linear regression model with covariate adjustment. We controlled the type 1 error in study-wide level by permutation method. The false discovery rate (FDR) and the family-wise error rate (FWER) were set to be 0.10 and 0.15 respectively. Results: Two SNPs were found to be significant (P

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0059035

DOI: 10.1371/journal.pone.0059035

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