Prognostic Value of Cancer Stem Cell Marker CD133 Expression in Gastric Cancer: A Systematic Review

Lei Wen, Xin-Zu Chen, Kun Yang, Zhi-Xin Chen, Bo Zhang, Jia-Ping Chen, Zong-Guang Zhou, Xian-Ming Mo and Jian-Kun Hu

PLOS ONE, 2013, vol. 8, issue 3, 1-5

Abstract: Objective: To investigate the correlation between CD133-positive gastric cancer and clinicopathological features and its impact on survival. Methods: A search in the Medline and Chinese CNKI (up to 1 Dec 2011) was performed using the following keywords gastric cancer, CD133, AC133, prominin-1 etc. Electronic searches were supplemented by hand searching reference lists, abstracts and proceedings from meetings. Outcomes included overall survival and various clinicopathological features. Results: A total of 773 gastric cancer patients from 7 studies were included. The median rate of CD133 expression by immunohistochemistry (IHC) was 44.8% (15.2%–57.4%) from 5 studies, and that by reverse transcription polymerase chain reaction (RT-PCR) was 91.3% (66.7%–100%) from 4 studies. The accumulative 5-year overall survival rates of CD133-positive and CD133-negative patients were 21.4% and 55.7%, respectively. Meta-analysis showed that CD133-positive patients had a significant worse 5-year overall survival compared to the negative ones (OR = 0.20, 95% CI 0.14–0.29, P

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0059154

DOI: 10.1371/journal.pone.0059154

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