Association of CYP2A6*4 with Susceptibility of Lung Cancer: A Meta-Analysis

Lishan Wang, Weidong Zang, Jiang Liu, Dongli Xie, Weidong Ji, Yaosheng Pan, Zhiqiang Li, Jiawei Shen and Yongyong Shi

PLOS ONE, 2013, vol. 8, issue 4, 1-5

Abstract: Objectives: To assess the association between the variant of Cytochrome P450 2A6 whole gene deletion (CYP2A6*4) polymorphism and risk of lung cancer. Methods: Two investigators independently searched the PubMed, Elsevier, EMBASE, Web of Science, Wiley Online Library and Chinese National Knowledge Infrastructure (CNKI). Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) for CYP2A6*4 and lung cancer were calculated in a fixed-effects model (the Mantel-Haenszel method) and a random-effects model (the DerSimonian and Laird method) when appropriate. Results: This meta-analysis included seven eligible studies, which included 2524 lung cancer cases and 2258 controls (cancer–free). Overall, CYP2A6*4 was associated with the risk of lung cancer (allele*4 vs. allele non-*4, pooled OR = 0.826, 95% CI = 0.725−0.941, P-value = 0.004). When stratifying for population, significant association was observed in Asian (additive model, pooled OR = 0.794, 95% CI = 0.694−0.909, P-value = 0.001; dominant model, pooled OR = 0.827, 95% CI = 0.709−0.965, P-value = 0.016; recessive model (pooled OR = 0.444, 95% CI = 0.293−0.675, P-value

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0059556

DOI: 10.1371/journal.pone.0059556

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