Association of L-Ficolin Levels and FCN2 Genotypes with Chronic Chagas Disease

Paola R Luz, Angelica B W Boldt, Caroline Grisbach, Jürgen F J Kun, Thirumalaisamy P Velavan and Iara J T Messias-Reason

PLOS ONE, 2013, vol. 8, issue 4, 1-8

Abstract: Background: L-ficolin (encoded by FCN2) binds to acetylated sugar moieties of many pathogens, including Trypanosoma cruzi, promoting their phagocytosis and lysis by the complement system. Methods: We investigated L-ficolin levels in 160 T. cruzi infected patients with chronic Chagas disease and 71 healthy individuals, and FCN2 polymorphisms (−986 G>A, −602 G>A, and −4 A>G in the promoter and A258S in exon 8) in 243 patients, being 88 indeterminate (asymptomatic), 96 with cardiac, 23 with digestive and 33 with cardiodigestive manifestations (two were unspecified) and 305 controls (135 for A258S). Results: Patients presented lower L-ficolin plasma levels than controls (p

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0060237

DOI: 10.1371/journal.pone.0060237

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