Melanopsin Gene Polymorphism I394T Is Associated with Pupillary Light Responses in a Dose-Dependent Manner

Shigekazu Higuchi, Akiko Hida, Sei-ichi Tsujimura, Kazuo Mishima, Akira Yasukouchi, Sang-il Lee, Youhei Kinjyo and Manabu Miyahira

PLOS ONE, 2013, vol. 8, issue 3, 1-5

Abstract: Background: Melanopsin-containing intrinsically photosensitive retinal ganglion cells (ipRGCs) play an important role in non-image forming responses to light, such as circadian photoentrainment, light-induced melatonin suppression, and pupillary light response. Although it is known that there are some single nucleotide polymorphisms (SNPs) in the melanopsin (OPN4) gene in humans, the associations of the SNPs with non-image forming responses to light remains unclear. In the present study, we examined the associations of melanopsin gene polymorphisms with pupillary light response. Methods: Japanese university students (mean age: 21.0±1.7 years) with the genotypes of TT (n = 38), TC (n = 28) and CC (n = 7) at rs1079610 (I394T) located in the coding region participated in the present study. They were matched by age and sex ratio. Dark-adapted pupil size (

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0060310

DOI: 10.1371/journal.pone.0060310

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