Smoking and Risk of Erectile Dysfunction: Systematic Review of Observational Studies with Meta-Analysis

Shiyi Cao, Xiaoxu Yin, Yunxia Wang, Hongfeng Zhou, Fujian Song and Zuxun Lu

PLOS ONE, 2013, vol. 8, issue 4, 1-6

Abstract: Background: There are many recent observational studies on smoking and risk of erectile dysfunction (ED) and whether smoking increases the risk of ED is still inconclusive. The objective of this meta-analysis was to synthesize evidence from studies that evaluated the association between smoking and the risk of ED. Methods: We searched PubMed, Embase, Web of Science, and Scopus in January 2013 to identify cohort and case-control studies that evaluated the association between smoking and ED. Study quality of included studies was assessed by the Newcastle-Ottawa scale. Random-effects meta-analyses were used to combine the results of included studies. Results: Four prospective cohort studies and four case-control studies involving 28, 586 participants were included. Because of significant heterogeneity after including case-control studies in meta-analysis, the consistent results of prospective cohort studies were considered more accurate, Because of significant heterogeneity after including case-control studies in meta-analysis, the consistent results of prospective cohort studies were considered more accurate, Compared with non-smokers, the overall odd ratio of ED in prospective cohort studies was 1.51(95% CI: 1.34 to 1.71) for current smokers, and it was 1.29 (95% CI: 1.07 to 1.47) for former smokers. Evidence of publication bias was not found. Conclusion: Evidence from epidemiological studies suggests that smoking, especially current smoking, may significantly increase the risk of ED

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0060443

DOI: 10.1371/journal.pone.0060443

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