Genetic Variants from Lipid-Related Pathways and Risk for Incident Myocardial Infarction

Ci Song, Nancy L Pedersen, Chandra A Reynolds, Maria Sabater-Lleal, Stavroula Kanoni, Christina Willenborg, the CARDIoGRAMplusC4D Consortium, Ann-Christine Syvänen, Hugh Watkins, Anders Hamsten, Jonathan A Prince and Erik Ingelsson

PLOS ONE, 2013, vol. 8, issue 3, 1-8

Abstract: Background: Circulating lipids levels, as well as several familial lipid metabolism disorders, are strongly associated with initiation and progression of atherosclerosis and incidence of myocardial infarction (MI). Objectives: We hypothesized that genetic variants associated with circulating lipid levels would also be associated with MI incidence, and have tested this in three independent samples. Setting and Subjects: Using age- and sex-adjusted additive genetic models, we analyzed 554 single nucleotide polymorphisms (SNPs) in 41 candidate gene regions proposed to be involved in lipid-related pathways potentially predisposing to incidence of MI in 2,602 participants of the Swedish Twin Register (STR; 57% women). All associations with nominal P

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0060454

DOI: 10.1371/journal.pone.0060454

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