Decreased Expression of Beclin 1 Correlates Closely with Bcl-xL Expression and Poor Prognosis of Ovarian Carcinoma

Huan-Xin Lin, Hui-Juan Qiu, Fei Zeng, Hui-Lan Rao, Guo-Fen Yang, Hsiang-Fu Kung, Xiao-Feng Zhu, Yi-Xin Zeng, Mu-Yan Cai and Dan Xie

PLOS ONE, 2013, vol. 8, issue 4, 1-10

Abstract: Background: It has been suggested that autophagy-related Beclin 1 plays a critical role in the regulation of tumor development and/or progression, but its prognostic significance and relationship with Bcl-xL expression in ovarian carcinoma are unclear. Methodology/Principal Findings: In the present study, the methods of Western blotting and immunohistochemistry (IHC) were utilized to investigate the expression status of Beclin 1 and Bcl-xL in fresh ovarian tissues and paraffin-embedded epithelial ovarian tumor tissues. Decreased expression of Beclin 1 was examined by IHC in 8.3% of normal ovaries, in 15.4% of cystadenomas, in 20.0% of borderline tumors, and in 55.6% of ovarian carcinomas, respectively. In ovarian carcinomas, decreased expression of Beclin 1 was correlated closely with ascending histological grade, later pT/pN/pM status and/or advanced clinical stage (P

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0060516

DOI: 10.1371/journal.pone.0060516

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