Recombinant Human Growth Hormone and Rosiglitazone for Abdominal Fat Accumulation in HIV-Infected Patients with Insulin Resistance: A Randomized, Double-Blind, Placebo-Controlled, Factorial Trial

Marshall J Glesby, Jeanine Albu, Ya-Lin Chiu, Kirsis Ham, Ellen Engelson, Qing He, Varalakshmi Muthukrishnan, Henry N Ginsberg, Daniel Donovan, Jerry Ernst, Martin Lesser and Donald P Kotler

PLOS ONE, 2013, vol. 8, issue 4, 1-12

Abstract: Background: Recombinant human growth hormone (rhGH) reduces visceral adipose tissue (VAT) volume in HIV-infected patients but can worsen glucose homeostasis and lipoatrophy. We aimed to determine if adding rosiglitazone to rhGH would abrogate the adverse effects of rhGH on insulin sensitivity (SI) and subcutaneous adipose tissue (SAT) volume. Methodology/Principal Findings: Randomized, double-blind, placebo-controlled, multicenter trial using a 2×2 factorial design in which HIV-infected subjects with abdominal obesity and insulin resistance were randomized to rhGH 3 mg daily, rosiglitazone 4 mg twice daily, combination rhGH + rosiglitazone, or double placebo (control) for 12 weeks. The primary endpoint was change in SI by frequently sampled intravenous glucose tolerance test from entry to week 12. Body composition was assessed by whole body magnetic resonance imaging (MRI) and dual Xray absorptiometry (DEXA). Conclusions/Significance: The addition of rosiglitazone abrogated the adverse effects of rhGH on insulin sensitivity and glucose tolerance while not significantly modifying the lowering effect of rhGH on VAT. Trial Registration: Clinicaltrials.gov NCT00130286

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0061160

DOI: 10.1371/journal.pone.0061160

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