GSTT1 Null Genotype Contributes to Lung Cancer Risk in Asian Populations: A Meta-Analysis of 23 Studies

Xin Yang, Man-Tang Qiu, Jing-Wen Hu, Xiao-xiao Wang, Feng Jiang, Rong Yin and Lin Xu

PLOS ONE, 2013, vol. 8, issue 4, 1-7

Abstract: Background: Genetic variation in glutathione S-transferases (GSTs) may contribute to lung cancer risk. Many studies have investigated the correlation between the Glutathione S-transferase T1 (GSTT1) null genotype and lung cancer risk in Asian population but yielded inconclusive results. Methodology/Principal Findings: We performed a meta-analysis of 23 studies including 4065 cases and 5390 controls. We assessed the strength of the association of GSTT1 with lung cancer risk and performed sub-group analyses by source of controls, smoking status, histological types, and sample size. A statistically significant correlation between GSTT1 null genotype and lung cancer in Asian population was observed (OR = 1.28, 95% CI = 1.10, 1.49; Pheterogeneity

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0062181

DOI: 10.1371/journal.pone.0062181

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