Adoptive Cellular Immunotherapy in Metastatic Renal Cell Carcinoma: A Systematic Review and Meta-Analysis

Xiaoyi Tang, Ting Liu, Xuefeng Zang, Hao Liu, Danhong Wang, Hu Chen and Bin Zhang

PLOS ONE, 2013, vol. 8, issue 5, 1-6

Abstract: Purpose: Metastatic renal cell carcinoma (mRCC), as one of the most immunogenic tumors has been the focus of adoptive cellular immunotherapy (ACI), but the effects of ACI on objective response and survival in patients with mRCC are still controversial. Therefore, a systematic review and meta-analysis was performed to address this issue. Methods: A search was conducted in the PubMed database for randomized clinical trials (RCTs) with ACI in mRCC. All included articles in this study were assessed according to the selection criteria and were divided into two groups: ACI versus no ACI. Outcomes were toxicity, objective response, 1-, 3- and 5-year survival. Risk ratio (RR) and 95% confidence intervals (CI) were calculated using a fixed-effects meta-analysis. Heterogeneity was measured by value of I2 or P. Results: 4 studies (469 patients) were included. Most of ACI-related adverse reactions were grade 1 or 2 and reversible. ACI provided significant benefit in terms of objective response (RR = 1.65; 95% CI, 1.15 to 2.38; P = 0.007, I2 = 49%), 1-year survival (RR = 1.30; 95% CI, 1.12 to 1.52; P = 0.0008, I2 = 0%), 3-year survival (RR = 2.76; 95% CI, 1.85 to 4.14; P

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0062847

DOI: 10.1371/journal.pone.0062847

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