Addition of a Novel, Protective Family History Category Allows Better Profiling of Cardiovascular Risk and Atherosclerotic Burden in the General Population. The Asklepios Study

Caroline M Van daele, Tim De Meyer, Marc L De Buyzere, Thierry C Gillebert, Simon L I J Denil, Sofie Bekaert, Julio A Chirinos, Patrick Segers, Guy G De Backer, Dirk De Bacquer, Ernst R Rietzschel and on behalf of the Asklepios Investigators

PLOS ONE, 2013, vol. 8, issue 5, 1-9

Abstract: Objectives: Whereas the importance of family history (FH) is widely recognized in cardiovascular risk assessment, its full potential could be underutilized, when applied with its current simple guidelines-based definition (cFH): presence of premature cardiovascular disease (CVD) in a first-degree relative. We tested the added value of a new, extended family history definition (eFH), also taking into account later onset of disease, second-degree relatives and number of affected relatives, on profiling cardiovascular risk and atherosclerotic burden in the general population. Design: longitudinal population study. Setting: random, representative population sample from Erpe-Mere and Nieuwerkerken (Belgium, primary care). Subjects: 2524 male/female volunteers, aged 35–55 years, free from overt CVD. Main outcome measures: Subjects were extensively phenotyped including presence of atherosclerosis (ultrasound) and a newly developed FH questionnaire (4 generations). Results: Compared to cFH, eFH was superior in predicting an adverse risk profile (glycemic state, elevated blood pressure, lipid abnormalities, presence of metabolic syndrome components) and presence of atherosclerosis (all age & sex-adjusted p

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0063185

DOI: 10.1371/journal.pone.0063185

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