The Genetic Variation of SORCS1 Is Associated with Late-Onset Alzheimer’s Disease in Chinese Han Population

Wei Xu, Jun Xu, Ying Wang, Huidong Tang, Yulei Deng, Rujing Ren, Gang Wang, Wenquan Niu, Jianfang Ma, Yiwen Wu, Jialin Zheng, Shengdi Chen and Jianqing Ding

PLOS ONE, 2013, vol. 8, issue 5, 1-8

Abstract: The variations of SORCS1 gene may play potential key roles in late-onset Alzheimer’s disease (LOAD). To evaluate the relationship between the polymorphism of SORCS1 gene and LOAD in the ethnic Han Chinese, we conducted a case–control study to investigate the association between the single-nucleotide polymorphisms (SNPs) in intron 1 of SORCS1 and LOAD in Chinese Han population. Six reported SNPs in intron 1 of SORCS1 were analyzed by Snapshot, genotyping and haplotyping in 236 Chinese LOAD cases and 233 matched controls. The significant differences in frequencies of two SNPs (rs10884402, rs950809) were found between the two groups. In addition, haplotype analyses revealed that, in the LOAD group, the frequency of haplotypes C-C-G-T-C (alleles in order of rs17277986, rs6584777, rs10884402, rs7078098, rs950809 polymorphisms) were significantly higher (Psim

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0063621

DOI: 10.1371/journal.pone.0063621

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