Meta-Analysis: Melatonin for the Treatment of Primary Sleep Disorders

Eduardo Ferracioli-Oda, Ahmad Qawasmi and Michael H Bloch

PLOS ONE, 2013, vol. 8, issue 5, 1-6

Abstract: Study Objectives: To investigate the efficacy of melatonin compared to placebo in improving sleep parameters in patients with primary sleep disorders. Design: PubMed was searched for randomized, placebo-controlled trials examining the effects of melatonin for the treatment of primary sleep disorders. Primary outcomes examined were improvement in sleep latency, sleep quality and total sleep time. Meta-regression was performed to examine the influence of dose and duration of melatonin on reported efficacy. Participants: Adults and children diagnosed with primary sleep disorders. Interventions: Melatonin compared to placebo. Results: Nineteen studies involving 1683 subjects were included in this meta-analysis. Melatonin demonstrated significant efficacy in reducing sleep latency (weighted mean difference (WMD) = 7.06 minutes [95% CI 4.37 to 9.75], Z = 5.15, p

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0063773

DOI: 10.1371/journal.pone.0063773

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