Serum C-Reactive Protein (CRP) as a Simple and Independent Prognostic Factor in Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type

Ya-Jun Li, Zhi-Ming Li, Yi Xia, Jia-Jia Huang, Hui-Qiang Huang, Zhong-Jun Xia, Tong-Yu Lin, Su Li, Xiu-Yu Cai, Zhi-Jun Wu-Xiao and Wen-Qi Jiang

PLOS ONE, 2013, vol. 8, issue 5, 1-9

Abstract: Background: C-reactive protein (CRP) is a biomarker of the inflammatory response, and it shows significant prognostic value for several types of solid tumors. The prognostic significance of CRP for lymphoma has not been fully examined. We evaluated the prognostic role of baseline serum CRP levels in patients with extranodal natural killer (NK)/T-cell lymphoma (ENKTL). Methods: We retrospectively analyzed 185 patients with newly diagnosed ENKTL. The prognostic value of the serum CRP level was evaluated for the low-CRP group (CRP≤10 mg/L) versus the high-CRP group (CRP>10 mg/L). The prognostic value of the International Prognostic Index (IPI) and the Korean Prognostic Index (KPI) were evaluated and compared with the newly developed prognostic model. Results: Patients in the high-CRP group tended to display increased adverse clinical characteristics, lower rates of complete remission (P 60 years, hypoalbuminemia, and elevated lactate dehydrogenase levels were independent adverse predictors of OS. Based on these four independent predictors, we constructed a new prognostic model that identified 4 groups with varying OS: group 1, no adverse factors; group 2, 1 factor; group 3, 2 factors; and group 4, 3 or 4 factors (P

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0064158

DOI: 10.1371/journal.pone.0064158

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