Perioperative Allogenenic Blood Transfusion Is Associated with Worse Clinical Outcomes for Hepatocellular Carcinoma: A Meta-Analysis

Lei Liu, Zhiwei Wang, Songqi Jiang, Bingfeng Shao, Jibing Liu, Suqing Zhang, Yilong Zhou, Yuan Zhou and Yixin Zhang

PLOS ONE, 2013, vol. 8, issue 5, 1-10

Abstract: Background and Objective: The impact of perioperative allogenenic blood transfusion (ABT) on clinical outcomes for hepatocellular carcinoma (HCC) is conflicting and unclear. The aim of this meta-analysis is to evaluate the association between ABT and HCC clinical outcomes. Outcomes evaluated were all-cause death, tumor recurrence and postoperative complications. Methods: Relevant articles were identified through MEDLINE search (up to November 2012). Meta-analyses were performed by using the fixed or random effect models. Study heterogeneity was assessed by Q-test and I2 test. Publication bias was evaluated by funnel plots, Egger′s and Begg’s test. Results: A total of 5635 cases from 22 studies finally met our inclusion criteria. Meta-analysis indicated HCC patients with ABT had an increased risk of all-cause death at 3 and 5 years after surgery (respectively: OR = 1.92, 95% CI, 1.61–2.29,P

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0064261

DOI: 10.1371/journal.pone.0064261

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