The Genetic Variant on Chromosome 10p14 Is Associated with Risk of Colorectal Cancer: Results from a Case-Control Study and a Meta-Analysis

Qin Qin, Li Liu, Rong Zhong, Li Zou, Jieyun Yin, BeiBei Zhu, BeiBei Cao, Wei Chen, Jigui Chen, Xiaorong Li, Tingting Li, Xuzai Lu, Jiao Lou, Juntao Ke, Sheng Wei, Xiaoping Miao and Shaofa Nie

PLOS ONE, 2013, vol. 8, issue 5, 1-9

Abstract: Background: A common single nucleotide polymorphism (SNP), rs10795668, located at 10p14, was first identified to be significantly associated with risk of colorectal cancer (CRC) by a genome-wide association study (GWAS) in 2008; however, another GWAS and following replication studies yielded conflicting results. Methods: We conducted a case-control study of 470 cases and 475 controls in a Chinese population and then performed a meta-analysis, integrating the current study and 9 publications to evaluate the association between rs10795668 and CRC risk. Heterogeneity among studies and publication bias were assessed by the χ2-based Q statistic test and Egger's test, respectively. Results: In the case-control study, significant association between the SNP and CRC risk was observed, with per-A-allele OR of 0.71 (95%CI: 0.54–0.94, P = 0.017). The following meta-analysis further confirmed the significant association, with per-A-allele OR of 0.91 (95%CI: 0.89–0.93, Pheterogeneity>0.05) in European population and 0.86 (95%CI: 0.78–0.96, Pheterogeneity

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0064310

DOI: 10.1371/journal.pone.0064310

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