Linking Protective GAB2 Variants, Increased Cortical GAB2 Expression and Decreased Alzheimer’s Disease Pathology

Fanggeng Zou, Olivia Belbin, Minerva M Carrasquillo, Oliver J Culley, Talisha A Hunter, Li Ma, Gina D Bisceglio, Mariet Allen, Dennis W Dickson, Neill R Graff-Radford, Ronald C Petersen, the Genetic and Environmental Risk for Alzheimer’s disease (GERAD1) Consortium, Kevin Morgan and Steven G Younkin

PLOS ONE, 2013, vol. 8, issue 5, 1-11

Abstract: GRB-associated binding protein 2 (GAB2) represents a compelling genome-wide association signal for late-onset Alzheimer’s disease (LOAD) with reported odds ratios (ORs) ranging from 0.75–0.85. We tested eight GAB2 variants in four North American Caucasian case-control series (2,316 LOAD, 2,538 controls) for association with LOAD. Meta-analyses revealed ORs ranging from (0.61–1.20) with no significant association (all p>0.32). Four variants were hetergeneous across the populations (all p

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0064802

DOI: 10.1371/journal.pone.0064802

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