Prognostic and Clinicopathological Significance of Survivin in Colorectal Cancer: A Meta-Analysis

Andreas Krieg, Thomas A Werner, Pablo E Verde, Nikolas H Stoecklein and Wolfram T Knoefel

PLOS ONE, 2013, vol. 8, issue 6, 1-8

Abstract: Survivin/BIRC5 is a potentially interesting prognostic marker and therapeutic target in colorectal cancer (CRC). However, the available data on survivin expression in CRC are heterogeneous. Thus, to clarify the prognostic relevance of survivin in patients with CRC and its association with clinicopathological parameters we performed a meta-analysis. We screened PubMed and EMBASE for those studies that investigated the prognostic value of survivin and its association with clinicopathological parameters in CRC. Data from eligible studies were extracted and included into the meta-analyses using a random effects model. Electronical literature search identified 15 studies including 1934 patients with CRC mostly detecting survivin by immunohistochemistry (IHC). Pooled hazard ratios of 11 studies that performed survival analysis revealed a positive correlation between survivin expression and poor prognosis (HR 1.93; 95% CI: 1.55–2.42; P

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0065338

DOI: 10.1371/journal.pone.0065338

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