Association of Polymorphism rs198977 in Human Kallikrein-2 Gene (KLK2) with Susceptibility of Prostate Cancer: A Meta-Analysis

Lishan Wang, Weidong Zang, Yunxia Sang, Dongli Xie, Li Wei, Weidong Ji, Yaosheng Pan, Zhiqiang Li, Jiawei Shen and Yongyong Shi

PLOS ONE, 2013, vol. 8, issue 6, 1-6

Abstract: Objectives: To assess the association of polymorphism rs198977 in the human kallikrein-2 gene (KLK2) and risk of prostate cancer (PCa). Methods: Two investigators independently searched the PubMed, Elsevier, EMBASE, Web of Science, Wiley Online Library and Chinese National Knowledge Infrastructure (CNKI). Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) for rs198977 and PCa were calculated in a fixed-effects model (the Mantel-Haenszel method) and a random-effects model (the DerSimonian and Laird method) when appropriate. Results: Six studies met the inclusion criteria in this meta-analysis, which included 5859 PCa cases and 4867 controls. Overall, rs198977 was associated with the PCa risk (TT+CT vs. CC, pooled OR = 1.163, 95% CI = 1.076–1.258, P-value

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0065651

DOI: 10.1371/journal.pone.0065651

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