Dressings Combined with Injection of Meglumine Antimoniate in the Treatment of Cutaneous Leishmaniasis: A Randomized Controlled Clinical Trial

Alireza Khatami, Rezvan Talaee, Makan Rahshenas, Ali Khamesipour, Pedram Mehryan, Sepideh Tehrani, Yahya Dowlati and Alireza Firooz

PLOS ONE, 2013, vol. 8, issue 6, 1-7

Abstract: Background: Cutaneous leishmaniasis (CL) is a neglected infectious disease and a major health problem in several developing countries. Despite some reasonable explanation for their potential benefits, there is only trace evidence regarding the role of dressings in the treatment of CL. Methods: This randomized, assessor-blind, controlled, clinical trial was conducted in an endemic area for CL caused by Leishmania major in Iran to assess the efficacy of administration of weekly intralesional meglumine antimoniate (i.l.MA) either alone or combined with application of a silver or a non-silver polyester dressing on their lesions for 6 weeks. After screening of 241 patients with CL lesions, 83 eligible patients with 158 lesions were randomly allocated in three arms of the study. Eligibility criteria included parasitologically confirmed CL, age of 12 to 60 years; willingness to participate, duration of lesion

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0066123

DOI: 10.1371/journal.pone.0066123

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