Association between Apolipoprotein E Gene Polymorphism and the Risk of Coronary Artery Disease in Chinese Population: Evidence from a Meta-Analysis of 40 Studies

Yan-Wei Yin, Qian-Qian Sun, Bei-Bei Zhang, Ai-Min Hu, Hong-Li Liu, Qi Wang and Zhi-Zhen Hou

PLOS ONE, 2013, vol. 8, issue 6, 1-11

Abstract: Background: Epidemiological studies have evaluated the association between apolipoprotein E (ApoE) gene polymorphism and coronary artery disease (CAD) risk which developed inconsistent conclusions. To derive a more precise estimation of the relationship in Chinese population, we performed this meta-analysis. Methods: Databases, including PubMed, EMbase, Web of Science, CBMdisc and CNKI, were searched to get the genetic association studies. Additionally, hand searching of the references of identified articles were performed. All the statistical tests were performed using Review Manager 5.1.2 and Stata 11.0. Results: We identified a total of 40 studies, including 4,564 CAD cases and 3,985 controls. The results showed evidence for significant association between ApoE ε4 allele and CAD risk (for ε2/ε4 vs. ε3/ε3: OR = 1.86, 95% CI = 1.42–2.43, p

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0066924

DOI: 10.1371/journal.pone.0066924

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