Job Strain and Cardiovascular Disease Risk Factors: Meta-Analysis of Individual-Participant Data from 47,000 Men and Women

Solja T Nyberg, Eleonor I Fransson, Katriina Heikkilä, Lars Alfredsson, Annalisa Casini, Els Clays, Dirk De Bacquer, Nico Dragano, Raimund Erbel, Jane E Ferrie, Mark Hamer, Karl-Heinz Jöckel, France Kittel, Anders Knutsson, Karl-Heinz Ladwig, Thorsten Lunau, Michael G Marmot, Maria Nordin, Reiner Rugulies, Johannes Siegrist, Andrew Steptoe, Peter J M Westerholm, Hugo Westerlund, Töres Theorell, Eric J Brunner, Archana Singh-Manoux, G David Batty, Mika Kivimäki and for the IPD-Work Consortium

PLOS ONE, 2013, vol. 8, issue 6, 1-6

Abstract: Background: Job strain is associated with an increased coronary heart disease risk, but few large-scale studies have examined the relationship of this psychosocial characteristic with the biological risk factors that potentially mediate the job strain – heart disease association. Methodology and Principal Findings: We pooled cross-sectional, individual-level data from eight studies comprising 47,045 participants to investigate the association between job strain and the following cardiovascular disease risk factors: diabetes, blood pressure, pulse pressure, lipid fractions, smoking, alcohol consumption, physical inactivity, obesity, and overall cardiovascular disease risk as indexed by the Framingham Risk Score. In age-, sex-, and socioeconomic status-adjusted analyses, compared to those without job strain, people with job strain were more likely to have diabetes (odds ratio 1.29; 95% CI: 1.11–1.51), to smoke (1.14; 1.08–1.20), to be physically inactive (1.34; 1.26–1.41), and to be obese (1.12; 1.04–1.20). The association between job strain and elevated Framingham risk score (1.13; 1.03–1.25) was attributable to the higher prevalence of diabetes, smoking and physical inactivity among those reporting job strain. Conclusions: In this meta-analysis of work-related stress and cardiovascular disease risk factors, job strain was linked to adverse lifestyle and diabetes. No association was observed between job strain, clinic blood pressure or blood lipids.

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0067323

DOI: 10.1371/journal.pone.0067323

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