Efficacy and Safety Profile of Combining Vandetanib with Chemotherapy in Patients with Advanced Non-Small Cell Lung Cancer: A Meta-Analysis

Wei Tian, Wenping Ding, Sungkyoung Kim, Leizhen Zheng, Li Zhang, Xiaoping Li, Jianchun Gu, Lian Zhang, Minggui Pan and Siyu Chen

PLOS ONE, 2013, vol. 8, issue 7, 1-10

Abstract: Objective: To evaluate the efficacy and safety profile of combining vandetanib with chemotherapy in patients with advanced non-small cell lung cancer (NSCLC). Methods: MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), ASCO Abstracts, ESMO Abstracts, Wanfang Database, CNKI were searched. Eligible studies were the randomized clinical trials (RCTs) that compared the efficacy and safety profile of adding vandetanib to chemotherapy with single chemotherapy in patients with advanced NSCLC. The outcomes included overall survival (OS), progression-free survival (PFS), overall response rate (ORR) and toxicities. All meta-analysis were performed using Review Manager 5.1. The fixed-effect model weighted by the Mantel-Haenszel method was used. When considerable heterogeneity was found (p 50%), further analysis (subgroup analysis, sensitivity analysis or random-effect model) was performed to identify potential cause. Results: Results reported from 5 RCTs involving 2284 patients were included in the analysis. Compared to chemotherapy alone, the addition of vandetanib resulted in a significant longer PFS (HR 0.79 [0.72–0.87], p

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0067929

DOI: 10.1371/journal.pone.0067929

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