Cortical Hand Bone Porosity and Its Association with Distal Radius Fracture in Middle Aged and Elderly Women

Alvilde Dhainaut, Mari Hoff, Unni Syversen and Glenn Haugeberg

PLOS ONE, 2013, vol. 8, issue 7, 1-6

Abstract: Objective: Reduced bone mineral density (BMD), assessed by Dual Energy X-ray absorptiometry (DXA), is a well-known risk factor for fragility fracture. A large proportion of patients with fracture have only slightly reduced BMD. Assessment of other bone structure features than BMD may improve identification of individuals at increased fracture risk. Digital X-ray radiogrammetry (DXR), which is a feasible tool for measurement of metacarpal cortical bone density, also gives an estimate of cortical bone porosity. Our primary aim was to explore the association between cortical porosity in the hand assessed by DXR and distal radius fracture. Methods: This case-control study included 123 women >50 years with distal radius fracture, and 170 controls. DXR was used to measure metacarpal BMD (DXR-BMD), cortical porosity (DXR-porosity), thickness (DXR-CT) and bone width (DXR-W) of the hand. Femoral neck BMD was measured by DXA. Results: The fracture group had a statistically significant lower DXR-BMD (0.492 vs. 0.524 g/cm2 p

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0068405

DOI: 10.1371/journal.pone.0068405

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