Transarterial Chemoembolization in Combination with Local Therapies for Hepatocellular Carcinoma: A Meta-Analysis

Mingheng Liao, Jiwei Huang, Tao Zhang and Hong Wu

PLOS ONE, 2013, vol. 8, issue 7, 1-

Abstract: Background: In previous randomized trials, transarterial chemoembolization (TACE) has shown an improvement of survival rate in hepatocellular carcinoma (HCC) when combined with radiofrequency ablation (RFA), percutaneous ethanol injection (PEI) or other therapies. The aim of this meta-analysis was to evaluate the effectiveness of combination therapy of TACE with RFA, PEI, radiotherapy (RT), three-dimensional conformal radiation therapy (3D-CRT) or High-Intensity Focused Ultrasound (HIFU). Methods: Randomized or nonrandomized studies comparing TACE combined with RFA, PEI, RT, 3D-CRT or HIFU with TACE alone for HCC were included. Meta-analysis was performed using a fix-effects model in RCTs and a random-effects model among the observational studies. Results: 10 randomized trials and 18 observational studies matched the selection criteria, including 2497 patients (682 in RCTs, 1815 in non-RCTs). Meta-analysis of RCTs showed that the combination of TACE and PEI ((RR)1-year=1.10, 95%CI=0.99-1.22, p=0.073; (RR)3-year=2.32, 95%CI=1.52-3.53, p

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0068453

DOI: 10.1371/journal.pone.0068453

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