Amyloid-Like Fibril Elongation Follows Michaelis-Menten Kinetics

Katazyna Milto, Akvile Botyriute and Vytautas Smirnovas

PLOS ONE, 2013, vol. 8, issue 7, 1-5

Abstract: A number of proteins can aggregate into amyloid-like fibrils. It was noted that fibril elongation has similarities to an enzymatic reaction, where monomers or oligomers would play a role of substrate and nuclei/fibrils would play a role of enzyme. The question is how similar these processes really are. We obtained experimental data on insulin amyloid-like fibril elongation at the conditions where other processes which may impact kinetics of fibril formation are minor and fitted it using Michaelis-Menten equation. The correlation of the fit is very good and repeatable. It speaks in favour of enzyme-like model of fibril elongation. In addition, obtained and values at different conditions may help in better understanding influence of environmental factors on the process of fibril elongation.

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0068684

DOI: 10.1371/journal.pone.0068684

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