Plasma Midregional Pro-Adrenomedullin Improves Prediction of Functional Outcome in Ischemic Stroke

Thomas Seifert-Held, Thomas Pekar, Thomas Gattringer, Nicole E Simmet, Hubert Scharnagl, Christoph Bocksrucker, Christian Lampl, Maria K Storch, Tatjana Stojakovic and Franz Fazekas

PLOS ONE, 2013, vol. 8, issue 7, 1-5

Abstract: Background: To evaluate if plasma levels of midregional pro-adrenomedullin (MR-proADM) improve prediction of functional outcome in ischemic stroke. Methods: In 168 consecutive ischemic stroke patients, plasma levels of MR-proADM were measured within 24 hours from symptom onset. Functional outcome was assessed by the modified Rankin Scale (mRS) at 90 days following stroke. Logistic regression, receiver operating characteristics (ROC) curve analysis, net reclassification improvement (NRI), and Kaplan-Meier survival analysis were applied. Results: Plasma MR-proADM levels were found significantly higher in patients with unfavourable (mRS 3–6) compared to favourable (mRS 0–2) outcomes. MR-proADM levels were entered into a predictive model including the patients' age, National Institutes of Health Stroke Scale (NIHSS), and the use of recanalization therapy. The area under the ROC curve did not increase significantly. However, category-free NRI of 0.577 (p

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0068768

DOI: 10.1371/journal.pone.0068768

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