Assessing Interactions between Common Genetic Variant on 2q35 and Hormone Receptor Status with Breast Cancer Risk: Evidence Based on 26 Studies

Tao Huang, Jun Hong, Wanlong Lin, Qungqing Yang, Keliang Ni, Qingyu Wu and Jie Sun

PLOS ONE, 2013, vol. 8, issue 8, 1-8

Abstract: Genome-wide association studies have identified 2q35-rs13387042 as a new breast cancer (BC) susceptibility locus in populations of European descent. Since then, the relationship between 2q35-rs13387042 and breast cancer has been reported in various ethnic groups; however, these studies have yielded inconsistent results. To investigate this inconsistency, we performed a meta-analysis of 26 studies involving a total of 101,529 cases and 167,363 controls for 2q35-rs13387042 polymorphism to evaluate its effect on genetic susceptibility for breast cancer. An overall random effects odds ratio of 1.14 (95% CI: 1.11–1.16, P

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0069056

DOI: 10.1371/journal.pone.0069056

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