A Novel Approach to Accounting for Loss to Follow-Up when Estimating the Relationship between CD4 Count at ART Initiation and Mortality

Matthew Fox, Owen McCarthy and Mead Over

PLOS ONE, 2013, vol. 8, issue 7, 1-9

Abstract: Background: While CD4 strongly predicts mortality on antiretroviral therapy (ART), estimates from programmatic data suffer from incomplete patient outcomes. Methods: We conducted a pooled analysis of one-year mortality data on ART accounting for lost patients. We identified articles reporting one-year mortality by ART initiation CD4 count. We estimated the average mortality among those lost as the value that maximizes the fit of a regression of the natural log of mortality on the natural log of the imputed mean CD4 count in each band. Results: We found 20 studies representing 64,426 subjects and 51 CD4 observations. Without correcting for losses, one-year mortality was >4.8% for all CD4 counts 500 had a one-year mortality

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0069300

DOI: 10.1371/journal.pone.0069300

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