Minimal Residual Disease-Based Risk Stratification in Chinese Childhood Acute Lymphoblastic Leukemia by Flow Cytometry and Plasma DNA Quantitative Polymerase Chain Reaction

Suk Hang Cheng, Kin Mang Lau, Chi Kong Li, Natalie P H Chan, Rosalina K L Ip, Chi Keung Cheng, Vincent Lee, Matthew M K Shing, Alex W K Leung, Shau Yin Ha, Daniel K L Cheuk, Anselm C W Lee, Chak Ho Li, Chung Wing Luk, Siu Cheung Ling, Ondrej Hrusak, Ester Mejstrikova, Yonna Leung and Margaret H L Ng

PLOS ONE, 2013, vol. 8, issue 7, 1-10

Abstract: Minimal residual disease, or MRD, is an important prognostic indicator in childhood acute lymphoblastic leukemia. In ALL-IC-BFM 2002 study, we employed a standardized method of flow cytometry MRD monitoring for multiple centers internationally using uniformed gating, and determined the relevant MRD-based risk stratification strategies in our local patient cohort. We also evaluated a novel method of PCR MRD quantitation using peripheral blood plasma. For the bone marrow flow MRD study, patients could be stratified into 3 risk groups according to MRD level using a single time-point at day-15 (Model I) (I-A: 10%), or using two time-points at day-15 and day-33 (Model II) (II-A: day-15

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0069467

DOI: 10.1371/journal.pone.0069467

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