Genetic Associations with Diabetes: Meta-Analyses of 10 Candidate Polymorphisms

Linlin Tang, Lingyan Wang, Qi Liao, Qinwen Wang, Leiting Xu, Shizhong Bu, Yi Huang, Cheng Zhang, Huadan Ye, Xuting Xu, Qiong Liu, Meng Ye, Yifeng Mai and Shiwei Duan

PLOS ONE, 2013, vol. 8, issue 7, 1-10

Abstract: Aims: The goal of our study is to investigate the combined contribution of 10 genetic variants to diabetes susceptibility. Methods: Bibliographic databases were searched from 1970 to Dec 2012 for studies that reported on genetic association study of diabetes. After a comprehensive filtering procedure, 10 candidate gene variants with informative genotype information were collected for the current meta-anlayses. Using the REVMAN software, odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the combined contribution of the selected genetic variants to diabetes. Results: A total of 37 articles among 37,033 cases and 54,716 controls were involved in the present meta-analyses of 10 genetic variants. Three variants were found to be significantly associated with type 1 diabetes (T1D): NLRP1 rs12150220 (OR = 0.71, 95% CI = 0.55–0.92, P = 0.01), IL2RA rs11594656 (OR = 0.86, 95% CI = 0.82–0.91, P

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0070301

DOI: 10.1371/journal.pone.0070301

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