Decrease of Fibulin-3 in Hepatocellular Carcinoma Indicates Poor Prognosis

Rongzhen Luo, Meifang Zhang, Lili Liu, Shixun Lu, Chris Zhiyi Zhang and Jingping Yun

PLOS ONE, 2013, vol. 8, issue 8, 1-11

Abstract: Fibulin-3, originally identified in senescent and Werner syndrome fibroblasts, has been implicated in cell morphology, growth, adhesion and motility. Fibulin-3 exhibits both antitumor and oncogenic activities towards human cancers; however, the role of Fibulin-3 in hepatocellular carcinoma (HCC) remains elusive. In this study, we showed that both the mRNA and protein levels of Fibulin-3 were remarkably downregulated in HCC cell lines and fresh tissues. Immunohistochemical data revealed that Fibulin-3 was decreased in tumorous tissues in 67.1% (171/255) of cases compared to the corresponding adjacent nontumorous tissues. The results of statistical analysis indicated that low Fibulin-3 expression, defined by the receiver operating characteristic curve (ROC), was significantly associated with tumor differentiation (P = 0.008), clinical stage (P = 0.014) and serum AFP levels (P

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0070511

DOI: 10.1371/journal.pone.0070511

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