Relationship of the p22phox (CYBA) Gene Polymorphism C242T with Risk of Coronary Artery Disease: A Meta-Analysis

Zhijun Wu, Yuqing Lou, Wei Jin, Yan Liu, Lin Lu, Qiujing Chen, Yucai Xie and Guoping Lu

PLOS ONE, 2013, vol. 8, issue 9, 1-14

Abstract: Background: Observational and experimental studies have thus far been unable to resolve whether the CYBA C242T polymorphism is associated with coronary artery disease (CAD). Therefore, we undertook a comprehensive meta-analysis to more precisely evaluate the influence of this polymorphism on CAD and potential biases. Methods: We screened MEDLINE, Embase, CNKI, Wanfang and CBM up to January 2013 and extracted data from 22 studies with 9,279 CAD patients and 9,349 controls. A random-effects model was exploited to synthesize the inconsistent outcomes of the individual studies, while addressing between-study heterogeneity and publication bias. Results: The CYBA C242T polymorphism conformed to Hard-Weinberg Equilibrium for all studies (P>0.05). Overall comparison of the T allele with the C allele produced a non-significant risk estimate for CAD but with striking heterogeneity (T versus C: P = 0.87, OR = 0.99, 95%CI 0.89–1.11, Pheterogeneity

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0070885

DOI: 10.1371/journal.pone.0070885

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