Periodontal Disease and Risk of Preeclampsia: A Meta-Analysis of Observational Studies

Ben-Juan Wei, Yi-Jun Chen, Li Yu and Bin Wu

PLOS ONE, 2013, vol. 8, issue 8, 1-6

Abstract: Background: Many epidemiological studies have found a positive association between periodontal disease (PD) and the risk of preeclampsia, but the magnitude of this association varies and independent studies have reported conflicting findings. We performed a meta-analysis to ascertain the relationship between PD and preeclampsia. Methods: The PubMed database was searched up to January 12, 2013, for relevant observational studies on an association between PD and the risk of preeclampsia. Data were extracted and analyzed independently by two authors. The meta-analysis was performed using comprehensive meta-analysis software. Results: Thirteen observational case-control studies and two cohort studies, involving 1089 preeclampsia patients, were identified. Based on a random-effects meta-analysis, a significant association between PD and preeclampsia was identified (odds ratio = 2.79, 95% confidence interval CI, 2.01–3.01, P

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0070901

DOI: 10.1371/journal.pone.0070901

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