Clinical Prediction in Early Pregnancy of Infants Small for Gestational Age by Customised Birthweight Centiles: Findings from a Healthy Nulliparous Cohort

Lesley M E McCowan, John M D Thompson, Rennae S Taylor, Robyn A North, Lucilla Poston, Philip N Baker, Jenny Myers, Claire T Roberts, Gustaaf A Dekker, Nigel A B Simpson, James J Walker, Louise C Kenny and on behalf of the SCOPE Consortium

PLOS ONE, 2013, vol. 8, issue 8, 1-12

Abstract: Objective: Small for gestational age (SGA) infants comprise up to 50% of all stillbirths and a minority are detected before birth. We aimed to develop and validate early pregnancy predictive models for SGA infants. Methods: 5628 participants from SCOPE, a prospective study of nulliparous pregnant women, were interviewed at 15±1 weeks’ gestation. Fetal anthropometry, uterine and umbilical Doppler studies were performed at 20±1 weeks’. The cohort was divided into training (n = 3735) and validation datasets (n = 1871). All-SGA (birthweight 12 months to conceive, university student, cigarette smoking, proteinuria, daily vigorous exercise and diastolic blood pressure ≥80. Recreational walking ≥4 times weekly, rhesus negative blood group and increasing random glucose were protective. AUC for clinical risk factors was 0.63. Fetal abdominal or head circumference z scores

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0070917

DOI: 10.1371/journal.pone.0070917

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