Hormone Replacement Therapy in Females Can Decrease the Risk of Lung Cancer: A Meta-Analysis

Yanwen Yao, Xiaoling Gu, Juehua Zhu, Dongmei Yuan and Yong Song

PLOS ONE, 2013, vol. 8, issue 8, 1-10

Abstract: The purpose of the present meta-analysis was to determine the relationship between hormone replacement therapy (HRT) and lung cancer risk in females. Publications were reviewed and obtained through a PubMed, EMBASE database and Cochrane Library literature search up to May, 2012. The detailed numbers of patients in different groups, odd ratios (ORs) and corresponding 95% confidence intervals (CIs) were collected and estimated using a random-effects model. Twenty five studies entered into the meta-analysis. The total number of participates and lung cancer patients was 656,403 and 11,442, respectively. The OR of all 25 studies was 0.91 (95%CI = 0.83 to 0.99) and P value was 0.033. In stratified analyses, the positive association between HRT use and decreased lung cancer risk was also found in the patients with BMI

Date: 2013
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0071236

DOI: 10.1371/journal.pone.0071236

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